Feasibility of pulse power application in cell biology and cancer treatment: a review
##plugins.themes.academic_pro.article.main##
Abstract
In this review paper after various reported data from 2000 to 2016 published in IEEE and science direct, are analyzed and discussed to explore the feasibility of pulsed power application in cell biology. Targeting inhabitation of cancer/tumor proliferation treatment as main fields, some other associated topics e.g. effect on plasma membrane, apoptosis induction etc. are investigated in vitro and in vivo, it summarizes, HOW the nano second Pulse Electric Field (nsPEF) affects eukaryotic cells that are healthy as well as that are affected by tumor/cancer i.e. unhealthy. Term electroporation came into the picture which stands for opening pore in cell membrane using pulse of electricity, to introduce DNA or chromosomes into bacteria or other cells. Width of the applied electrical pulse used also caused different cellular effects, pulses longer than 100μs, in electroporation, delivers DNA, protein, small drugs and fluorescent indicators across the plasma membrane and causes moderate levels of Phosphatidyl Serine (PS) translocation at the Plasma Membrane, while shorter pulses less than 1μs are central to intracellular effects such as apoptosis induction (programmed cell death) and higher levels of Phosphatidyl Serine (PS) translocation. In addition, nsPEFs acts as cellular stress that introduces translational suppression. Ultra-short electricity i.e. nsPEFs can reach intra cellular component directly without membrane destruction causes apoptosis induction (programmed cell death). Also it has been found that direct current produced by applied voltage induces specific biological healing of tissues near the electrodes, also the effect of current is same as in ionizing radiation of tumor therapy. Chemotherapeutic drugs along with nsPEF reduces dose of both types of treatments. Also, nsPEFs causes transient activation of signaling pathways involving Mitogen-Activated Protein Kinases (MAPKs). Now days, nsPEFs are recognized as unique tool in life science.
##plugins.themes.academic_pro.article.details##
How to Cite
Kumar, G., Sharma, A., & Sarathi, R. (2017). Feasibility of pulse power application in cell biology and cancer treatment: a review. Power Research - A Journal of CPRI, 117–124. Retrieved from https://node6473.myfcloud.com/~geosocin/CPRI/index.php/pr/article/view/145
References
- Lamberti, V. Tucci, S. Romeo, A. Sannino, M. R. Scarfì and O. Zeni, "nsPEFinduced effects on cell membranes: use of electrophysical model to optimize experimental design," in IEEE Transactions on Dielectrics and Electrical Insulation, Vol. 20, No. 4, pp. 1231-1238, August 2013.
- Thiruvallur R. Gowrishankar, Axel T. Esser, Zlatko Vasilkoski, Kyle C. Smith, James C. Weaver, “Microdosimetry for conventional and supra-electroporation in cells with organelles” Biochem, Biophysics Res Common Vol. 341, pp. 1266-1276.
- K. H. Schoenbach, S. Katsuki, R. H. Stark, E. S. Buescher and S. J. Beebe, "Bioelectrics new applications for pulsed power technology," in IEEE Transactions on Plasma Science, Vol. 30, No. 1, pp. 293300, Feb 2002.
- K. H. Schoenbach, F. E. Peterkin, R. W. Alden and S. J. Beebe, "The effect of pulsed electric fields on biological cells: experiments and applications," in IEEE Transactions on Plasma Science, Vol. 25, No. 2, pp. 284-292, Apr 1997.
- S. J. Beebe, P. M. Fox, L. J. Rec, K. Somers, R. H. Stark and K. H. Schoenbach, "Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition," in IEEE Transactions on Plasma Science, Vol. 30, No. 1, pp. 286-292, Feb 2002.
- P. Kirawanich, N. Pausawasdi, C. Srisawat, S. J. Yakura and N. E. Islam, "An FDTD Interaction Scheme of a High-Intensity Nanosecond-Pulsed Electric-Field System for In Vitro Cell Apoptosis Applications," in IEEE Transactions on Plasma Science, Vol. 38, No. 10, pp. 2574-2582, Oct. 2010.
- M. Nagahama, N. Shimomura, A. Nakagawa, K. Teranishi, Y. Uto and H. Hori, "In vivo experimental study of nanosecond pulsed electric field effects on solid tumors," in IEEE Transactions on Dielectrics and Electrical Insulation, Vol. 20, No. 4, pp. 1266-1272, August 2013.
- A. Nakagawa, M. Nagahama, K. Teranishi, Y. Uto and N. Shimomura, "Effects of applied ultrashort pulsed electric fields on solid tumor," 2014 IEEE International Power Modulator and High Voltage Conference (IPMHVC), Santa Fe, NM, pp. 45-48, 2014,
- S. Matsubara, A. Nakagawa, S. Kuniyasu, K. Teranishi, Y. Uto and N. Shimomura, "Investigation of effect of applied nanosecond pulsed electric fields on tumor," 2015 IEEE Pulsed Power Conference (PPC), Austin, TX, pp. 1-5, 2015
- Chenguo Yao et al., "Experiment and mechanism research of SKOV3 cancer cell apoptosis induced by nanosecond pulsed electric field," 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vancouver, BC, pp. 1044-1047, 2008.
- S. J. Beebe, X. Chen, J. A. Liu and K. H. Schoenbach, "Nanosecond pulsed electric field ablation of hepatocellular carcinoma," 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, pp. 6861-6865, 2011,
- K. Mitsutake, A. Satoh, S. Mine, K. Abe, S. Katsuki and H. Akiyama, "Effect of pulsing sequence of nanosecond pulsed electric fields on viability of HeLa S3 cells," in IEEE Transactions on Dielectrics and Electrical Insulation, Vol. 19, No. 1, pp. 337-342, February 2012.
- R. Sundararajan et al., "Effective proliferation control of human cancer cells using electrical pulses," in IEEE Transactions on Dielectrics and Electrical Insulation, Vol. 19, No. 6, pp. 2225-2236, December 2012.
- S. Wu, J. Guo, B. Su, J. Zhang and J. Fang, "Nanosecond pulsed electric fields adjuvant chemotherapy for breast cancer: An in vitro study," 2013 19th IEEE Pulsed Power Conference (PPC), San Francisco, CA, pp. 1-5, 2013.
- K. Mitsutake, A. Satoh, S. Mine, K. Abe, S. Katsuki and H. Akiyama, "Study of effect of pulsing sequence of nanosecond pulsed electric fields on viability of HeLa S3 cell," 2010 IEEE International Power Modulator and High Voltage Conference, Atlanta, GA, pp. 204-207, 2010,
- R. Bose and S. Chatterjee, "Comparative study of electrode configurations in different brain tumor geometry for effective Electrochemotherapy," 2016 3rd International Conference on Recent Advances in Information Technology (RAIT), Dhanbad, pp. 667-671, 2016,
- S. Rui, Y. Mi, L. Liu, C. Yao and C. Li, "Study on temperature of liver and tumor under high frequency nanosecond pulsed field," 2015 IEEE Pulsed Power Conference (PPC), Austin, TX, pp. 1-5, 2015,